Mitochondria-lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [bulk RNA-seq]
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × WT Treg vs 5 × Flcn KO TregGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mitochondrial and lysosomal signaling orchestrates heterogeneous metabolic states of regulatory T cellsScience immunology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264047_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1100603 and SRA study SRP501924. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8209154 WT Treg rep1 WT Treg
- GSM8209155 WT Treg rep2 WT Treg
- GSM8209156 WT Treg rep3 WT Treg
- GSM8209157 WT Treg rep4 WT Treg
- GSM8209158 WT Treg rep5 WT Treg
- GSM8209159 Flcn KO Treg rep1 Flcn KO Treg
- GSM8209160 Flcn KO Treg rep2 Flcn KO Treg
- GSM8209161 Flcn KO Treg rep3 Flcn KO Treg
- GSM8209162 Flcn KO Treg rep4 Flcn KO Treg
- GSM8209163 Flcn KO Treg rep5 Flcn KO Treg
- GSE262495 Mitochondria–lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [scRNA-seq2] 5 samples shares inflammation-associated, immunopathology, progressive, crosstalk, dictates, rna-seq, limit
- GSE263803 Mitochondria–lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [scRNA-seq3] 4 samples shares inflammation-associated, immunopathology, progressive, crosstalk, dictates, rna-seq, limit
- GSE262494 Mitochondria–lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [scRNA-seq1] 8 samples shares inflammation-associated, immunopathology, progressive, crosstalk, dictates, rna-seq, limit
- GSE263802 Mitochondria-lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [ATAC-seq2] 7 samples shares inflammation-associated, mitochondria-lysosome, immunopathology, progressive, crosstalk, dictates, limit
- GSE262691 Mitochondria–lysosome crosstalk dictates the progressive differentiation of Treg cells to limit inflammation-associated immunopathology [ATAC-seq1] 8 samples shares inflammation-associated, immunopathology, progressive, crosstalk, dictates, limit
- GSE312491 Single-Cell Profiling Reveals Mediators of Immune-Vascular Crosstalk in Mouse Models of Relapsing and Progressive Multiple Sclerosis 4 samples shares progressive, crosstalk
- GSE269493 Hepatoprotective effects of late-stage clinical drug candidates and dietary intervention in the non-obese CDAA-HFD mouse model of advanced MASH with progressive fibrosis 81 samples shares progressive
- GSE317471 Single-cell analysis of the progeric vascular wall reveals progressive cell-type specific dysfunction and accumulation of somatic mutations 30 samples shares progressive
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.