Resilience to Endoplasmic Reticulum Stress Mitigates Calcium-Dependent Membrane Hyperexcitability Underlying Late Disease Onset in Spinocerebellar Ataxia Type 6
RNA-seq (gene expression) · mouse · 40 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 40 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6Annals of neurology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264100_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1100988 and SRA study SRP502133. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 40 more — browse all 40 samples with per-sample file links →
- GSE194200 Induction of transient and adaptive vs maladaptive unfolded protein responses of the endoplasmic reticulum in pancreatic beta cells 39 samples shares endoplasmic, reticulum
- GSE326835 MANF in the Lateral Septum Dynamically Regulates Endoplasmic Reticulum Function via Transcriptomic Remodeling in Chronic Social Defeat Stress Response 24 samples shares endoplasmic, reticulum
- GSE312618 Endoplasmic Reticulum Associated Lipolysis Regulates Hepatic Fat Synthesis and Turnover [RNA-seq] 23 samples shares endoplasmic, reticulum
- GSE304359 Tmem45b Modulates itch via Endoplasmic Reticulum Calcium Regulation 21 samples shares endoplasmic, reticulum
- GSE282680 Uncontrolled endoplasmic reticulum stress response leads to pancreatic beta cell death via JNK andp53 16 samples shares endoplasmic, reticulum
- GSE318827 SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis [KPK_Slc33a1_KO_TUNC] 12 samples shares endoplasmic, reticulum
- GSE235042 Inhibition of endoplasmic reticulum stress prevents renal pathology in hindlimb unloaded mice 9 samples shares endoplasmic, reticulum
- GSE317334 Meningeal Lymphatic Vessel Dysfunction Exacerbates Brain Injury in CVST Mice via Endoplasmic Reticulum and Oxidative Stress Pathways. 9 samples shares endoplasmic, reticulum
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.