Hypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in Neuroblastoma
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- NeuroblastomaThis series is part of our curated briefing on it.
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hypoxia Promotes an Adrenergic to Mesenchymal Transcriptional Program Transition in NeuroblastomaClinical and translational science · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE264118_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1101015 and SRA study SRP502118. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8212248 55N cells, hypoxia, rep1 55N cells, hypoxia,
- GSM8212249 55N cells, hypoxia, rep2 55N cells, hypoxia,
- GSM8212250 55N cells, hypoxia, rep3 55N cells, hypoxia,
- GSM8212251 5S cells, hypoxia, rep1 5S cells, hypoxia,
- GSM8212252 5S cells, hypoxia, rep2 5S cells, hypoxia,
- GSM8212253 5S cells, hypoxia, rep3 5S cells, hypoxia,
- GSM8212254 BE2 cells, hypoxia, rep1 BE2 cells, hypoxia,
- GSM8212255 BE2 cells, hypoxia, rep2 BE2 cells, hypoxia,
- GSM8212256 BE2 cells, hypoxia, rep3 BE2 cells, hypoxia,
- GSM8212257 NBLS cells, hypoxia, rep1 NBLS cells, hypoxia,
- GSM8212258 NBLS cells, hypoxia, rep2 NBLS cells, hypoxia,
- GSM8212259 NBLS cells, hypoxia, rep3 NBLS cells, hypoxia,
- GSM8212260 SHEP cells, hypoxia, rep1 SHEP cells, hypoxia,
- GSM8212261 SHEP cells, hypoxia, rep2 SHEP cells, hypoxia,
- GSM8212262 SHEP cells, hypoxia, rep3 SHEP cells, hypoxia,
- GSM8212263 SY5Y cells, hypoxia, rep1 SY5Y cells, hypoxia,
- GSM8212264 SY5Y cells, hypoxia, rep2 SY5Y cells, hypoxia,
- GSM8212265 SY5Y cells, hypoxia, rep3 SY5Y cells, hypoxia,
- GSM8212266 WN cells, hypoxia, rep1 WN cells, hypoxia,
- GSM8212267 WN cells, hypoxia, rep2 WN cells, hypoxia,
- GSM8212268 WN cells, hypoxia, rep3 WN cells, hypoxia,
- GSM8212269 WS cells, hypoxia, rep1 WS cells, hypoxia,
- GSM8212270 WS cells, hypoxia, rep2 WS cells, hypoxia,
- GSM8212271 WS cells, hypoxia, rep3 WS cells, hypoxia,
- GSE164456 Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma 69 samples same disease briefing · shares neuroblastoma, adrenergic, program
- GSE167478 MYCN directly regulates TET1 expression to control 5-hmC distribution and enhance neuroblastoma cell migration in hypoxia 22 samples same disease briefing · shares neuroblastoma, hypoxia
- GSE167475 MYCN directly regulates TET1 expression to control 5-hmC distribution and enhance neuroblastoma cell migration in hypoxia [hMe-SEAL] 7 samples same disease briefing · shares neuroblastoma, hypoxia
- GSE183729 Single-cell MultiOmics and spatial transcriptomics demonstrate neuroblastoma developmental plasticity 18 samples same disease briefing · shares neuroblastoma
- GSE178937 RNA sequencing of neuroblastoma cells treated with selinexor or with XPO1 knockdown 12 samples same disease briefing · shares neuroblastoma
- GSE275538 Identification of EPLIN as a novel MYCN-independent target in neuroblastoma and medulloblastoma 1 samples same disease briefing · shares neuroblastoma
- GSE120572 A mechanistic classification of clinical phenotypes in neuroblastoma 394 samples same disease briefing · shares neuroblastoma
- GSE181582 IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression 264 samples same disease briefing · shares neuroblastoma
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.