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Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans [bulkRNAseq_MouseLPL]

GSE264463 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/24 Platform GPL24247
Summary
To understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from UC patients and controls. We identified colonic CD4+ and CD8+ T lymphocyte subsets with gene expression profiles resembling stem-like progenitors, previously reported in animal models of diabetes and other contexts. Stem-like T cells were increased in inflamed areas compared to non-inflamed regions from the same patients. Furthermore, TCR sequence analysis indicated stem-like T cells were clonally related to pro-inflammatory T cells, suggesting their involvement in sustaining effectors that drive inflammation. Using an adoptive transfer colitis model, we demonstrated that CD4+ T cells deficient in BCL-6, a transcription factor promoting T cell stemness, had decreased colon T cells, reduced TH17 cells, and diminished pathogenicity. Our results establish a strong association between stem-like T cell populations and UC pathogenesis, highlighting the potential of targeting this population to improve clinical outcomes.
Published in
Stem-like T cells are associated with the pathogenesis of ulcerative colitis in humans
Li Y, Ramírez-Suástegui C, Harris R et al. · Nature immunology 2024 · PMID 38898157 · doi:10.1038/s41590-024-01860-7
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Also filed as BioProject PRJNA1102437 and SRA study SRP502933. Searching any of these in the dataset finder brings you back here.

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