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Sequencing to Explore the Mechanism Network of N-acetyltransferase 10 (NAT10) Promoting Colorectal cancer in human colorectal cancer cell SW620

GSE264582 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/12 Platform GPL24676
Summary
N-acetyltransferase 10 (NAT10), the only known mRNA ac4C “writer,” plays a significant role in several human diseases, including CRC and gastric cancer. As NAT10 can activate or repress important signaling pathways, such as the EMT pathway, DNA damage repair, or apoptosis, by catalyzing the ac4C modification of oncogene mRNA, targeting NAT10 shows great potential for inhibiting cancer cell malignant progression in vitro and in vivo. This complex network of colorectal cancer progression mediated by NAT10 remains to be identified, which can expand cancer therapy options. To identify potential NAT10-regulated ac4C targets, we checked mRNA sequencing in human colorectal cancer cell SW620.
Published in
EGFR inhibition augments the therapeutic efficacy of the NAT10 inhibitor Remodelin in Colorectal cancer
Zheng Y, Song D, Guo M et al. · Journal of experimental & clinical cancer research : CR 2025 · PMID 39905540 · doi:10.1186/s13046-025-03277-y
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Also filed as BioProject PRJNA1103189 and SRA study SRP503407. Searching any of these in the dataset finder brings you back here.

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