An infectious murine model for hepacivirus-associated fibrosis and hepatocellular carcinoma
RNA-seq (gene expression) · mouse · 161 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 161 samples: 139 distinct titles, 22 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- An immunocompetent murine model of virus-elicited liver fibrosis and hepatocellular carcinomaJournal of hepatology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE265927_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1104985 and SRA study SRP504184. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 119 samples read as cases, 42 as controls.
How we read this: Read from 161 sample titles: 139 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8232068 Mouse 2501, female, infected, 7 mo
- GSM8232069 Mouse 2512, female, infected, 7 mo
- GSM8232070 Mouse 2537, female, infected, 7 mo
- GSM8232071 Mouse 2538, female, infected, 7 mo
- GSM8232072 Mouse 2547, female, infected, 7 mo
- GSM8232073 Mouse 2548, female, infected, 7 mo
- GSM8232074 Mouse 2568, female, infected, 7 mo
- GSM8232075 Mouse 2569, female, infected, 7 mo
- GSM8232076 Mouse 2521, female, mock, 7 mo
- GSM8232077 Mouse 2522, female, mock, 7 mo
- GSM8232078 Mouse 2534, female, mock, 7 mo
- GSM8232079 Mouse 2557, female, mock, 7 mo
- GSM8232080 Mouse 2558, female, mock, 7 mo
- GSM8232081 Mouse 2588, female, mock, 7 mo
- GSM8232082 Mouse 2506, male, infected, 7 mo
- GSM8232083 Mouse 2507, male, infected, 7 mo
- GSM8232084 Mouse 2516, male, infected, 7 mo
- GSM8232085 Mouse 2517, male, infected, 7 mo
- GSM8232086 Mouse 2542, male, infected, 7 mo
- GSM8232087 Mouse 2543, male, infected, 7 mo
- GSM8232088 Mouse 2552, male, infected, 7 mo
- GSM8232089 Mouse 2553, male, infected, 7 mo
- GSM8232090 Mouse 2527, male, mock, 7 mo
- GSM8232091 Mouse 2528, male, mock, 7 mo
- GSM8232092 Mouse 2532, male, mock, 7 mo
- GSM8232093 Mouse 2533, male, mock, 7 mo
- GSM8232094 Mouse 2562, male, mock, 7 mo
- GSM8232095 Mouse 2563, male, mock, 7 mo
- GSM8232096 Mouse 2503, female, infected, 12 mo
- GSM8232097 Mouse 2504, female, infected, 12 mo
- GSM8232098 Mouse 2505, female, infected, 12 mo
- GSM8232099 Mouse 2513, female, infected, 12 mo
- GSM8232100 Mouse 2514, female, infected, 12 mo
- GSM8232101 Mouse 2515, female, infected, 12 mo
- GSM8232102 Mouse 2523, female, mock, 12 mo
- GSM8232103 Mouse 2524, female, mock, 12 mo
- GSM8232104 Mouse 2525, female, mock, 12 mo
- GSM8232105 Mouse 2535, female, mock, 12 mo
- GSM8232106 Mouse 2536, female, mock, 12 mo
- GSM8232107 Mouse 2549, female, infected, 12 mo
+ 121 more — browse all 161 samples with per-sample file links →
- GSE308969 The origin of hepatocellular carcinoma is regulated by metabolic zonation 31 samples shares hepatocellular
- GSE291594 Single-cell analysis of immune cell characteristics induced by Aoah over-expression in MYC-Luc spontaneous hepatocellular carcinoma tumors 24 samples shares hepatocellular
- GSE249325 Development Of Pre-Clinical Murine Models For Fibrolamellar Hepatocellular Carcinoma 19 samples shares hepatocellular
- GSE314584 Toll-Like-Receptor 5 Reduces Lung Dysbiosis and Protects Against Pulmonary Fibrosis 124 samples shares fibrosis
- GSE246213 A Mouse Model for Metabolic Dysfunction-associated Steatotic Liver Disease and Hepatocellular Carcinoma [ATAC-seq] 12 samples shares hepatocellular
- GSE302836 Loss of Hepatocyte PI3Ka Protects Mice from Hepatocellular Carcinoma in association with altered lipid metabolism gene expression 42 samples shares hepatocellular
- GSE291235 Effect of myeloid specific Trem2 knockout in hepatocellular carcinoma after anti-PD-1 therapy 30 samples shares hepatocellular
- GSE308568 The origin of hepatocellular carcinoma is regulated by metabolic zonation [RNA-seq] 26 samples shares hepatocellular
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.