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Temporary Alleviation of MAPK by Arbutin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells

GSE265933 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/05 Platform GPL24676
Summary
Dry age-related macular degeneration (AMD) is one of the main diseases that causes blindness in humans and the number of cases is increasing every year, but effective treatments are not available, arbutin (ARB) has been reported to have antioxidant, anti-inflammatory, and anti-aging effects in other age-related diseases. However, whether it can help treat dry AMD remains unknown.in this study, we found 10-100 μM ARB concentration-dependently reversed the H2O2-induced viability decline in HRPECs, and ARB inhibited H2O2-induced HRPEC ROS production and apoptosis by changing the expression of antioxidant and apoptosis-related genes and proteins. Transcriptome sequencing and western blotting showed that ARB reduced ERK1/2 and P-38 phosphorylation to prevent H2O2-induced oxidation damage. We concluded ARB reversed the H2O2-induced decline in HRPEC activity, which was related to inhibition of ROS production and apoptosis. The ERK1/2 and P38 MAPK signaling pathways may have mediated this process.
Published in
Temporary alleviation of MAPK by arbutin alleviates oxidative damage in the retina and ARPE-19 cells
Wang L, Tian Y, Li L et al. · Heliyon 2024 · PMID 38988586 · doi:10.1016/j.heliyon.2024.e32887
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Also filed as BioProject PRJNA1104996 and SRA study SRP504344. Searching any of these in the dataset finder brings you back here.

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