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Simultaneous treatment of castration-resistant prostate cancer cells with the DNA Demethylating Agent Decitabine and S-adenosylmethionine leads to synergistic anti- cancer effects.

GSE266129 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/01/02 Platform GPL23227
Summary
A general problem of methylating and demethylating agents is a lack of limitation to the promotors of tumor suppressor genes or proto-oncogenes respectively. This may cause adverse consequences. Thus, the question was raised if the simultaneous application of DNA-demethylating agents and S-adenosylmethionine could reverse these effects.
Published in
The Simultaneous Treatment of PC-3 Cells with the DNA-Demethylating Agent Decitabine and S-Adenosylmethionine Leads to Synergistic Anticancer Effects
Schmidt T, Sticht C · Genes 2024 · PMID 39766901 · doi:10.3390/genes15121634
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Also filed as BioProject PRJNA1105942 and SRA study SRP504666. Searching any of these in the dataset finder brings you back here.

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