Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome.
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 45 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 45 samples: 33 distinct titles, 10 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylomeCell stem cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266196_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1106282 and SRA study SRP504851. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 45 sample titles: 33 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8242184 BTS11_C1_RNA-seq
- GSM8242185 BTS11_C2_RNA-seq
- GSM8242186 BTS11_C3_RNA-seq
- GSM8242187 DNMT3L_OE_BTS11_1_RNA-seq
- GSM8242188 DNMT3L_OE_BTS11_2_RNA-seq
- GSM8242189 DNMT3L_OE_BTS11_3_RNA-seq
- GSM8242190 BTS11_1_H3K36me3
- GSM8242191 BTS11_1_H3K4me3
- GSM8242192 BTS11_1_H3K27me3
- GSM8242193 BTS11_1_H3K9me3
- GSM8242194 BTS11_1_Input
- GSM8242195 BTS11_2_H3K4me3
- GSM8242196 BTS11_2_H3K27me3
- GSM8242197 BTS11_2_H3K9me3
- GSM8242198 BTS11_2_Input
- GSM8242199 CT29_1_H3K4me3
- GSM8242200 CT29_1_H3K27me3
- GSM8242201 CT29_1_H3K9me3
- GSM8242202 CT29_2_H3K4me3
- GSM8242203 CT29_2_H3K27me3
- GSM8242204 CT29_2_H3K9me3
- GSM8242205 CT29_2D_21_OM1
- GSM8242206 CT29_2D_21_OM2
- GSM8242207 CT29_2D_21_TOM
- GSM8242208 BTS11_2D_21_OM1
- GSM8242209 BTS11_2D_21_OM2
- GSM8242210 BTS11_2D_21_TOM
- GSM8242211 BTS11_3D_21_TOM1
- GSM8242212 BTS11_3D_21_TOM2
- GSM8242213 CT29_3D_21_TOM1
- GSM8242214 CT29_3D_21_TOM2
- GSM8242215 BTS11_3D_5_TOM1
- GSM8242216 BTS11_3D_5_TOM2
- GSM8242217 CT29_3D_5_TOM1
- GSM8242218 CT29_3D_5_TOM2
- GSM8242219 BTS11_C1
- GSM8242220 BTS11_C2
- GSM8242221 BTS11_C3
- GSM8242222 DNMT3L_OE_BTS11_1
- GSM8242223 DNMT3L_OE_BTS11_2
+ 5 more — browse all 45 samples with per-sample file links →
- GSE266194 Ectopic expression of DNMT3L in human trophoblast stem cells restores features of the placental methylome [ChIP-seq] 15 samples shares dnmt3l, trophoblast, placental, methylome, restores, features, ectopic, stem
- GSE280039 METTL3 safeguards cell identity and epigenome of human trophoblast stem cells 78 samples shares trophoblast, stem
- GSE276594 Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells [RNA-Seq 2] 45 samples shares trophoblast, stem
- GSE278374 PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [ChIP-seq] 44 samples shares trophoblast, stem
- GSE236796 Specificity protein 6 governs human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements 42 samples shares trophoblast, stem
- GSE311483 BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia 32 samples shares trophoblast, placental
- GSE278375 PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [RNA-seq] 32 samples shares trophoblast, stem
- GSE299501 HAND1 controls the lineage divergence between amnion and trophoblast from human pluripotent stem cells 27 samples shares trophoblast, stem
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.