PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [RNA-seq]
RNA-seq (gene expression) · human · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 32 samples: 16 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblastsNucleic acids research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE278375_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1166892 and SRA study SRP535591. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
How we read this: 16 replicated groups read from 32 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8545590 TSC_Ctrl_KD_rep1 TSC_Ctrl_KD
- GSM8545591 TSC_Ctrl_KD_rep2 TSC_Ctrl_KD
- GSM8545592 TSC_PPARG_KD1 TSC_PPARG_KD
- GSM8545593 TSC_PPARG_KD2 TSC_PPARG_KD
- GSM8545594 EVTd3_T007_Ctrl_rep1 EVTd3_T007_Ctrl
- GSM8545595 EVTd3_T007_Ctrl_rep2 EVTd3_T007_Ctrl
- GSM8545596 EVTd3_T007_LGD_rep1 EVTd3_T007_LGD
- GSM8545597 EVTd3_T007_LGD_rep2 EVTd3_T007_LGD
- GSM8545598 EVTd3_T007_rep1 EVTd3_T007
- GSM8545599 EVTd3_T007_rep2 EVTd3_T007
- GSM8545600 EVTd8_Ctrl_KD_rep1 EVTd8_Ctrl_KD
- GSM8545601 EVTd8_Ctrl_KD_rep2 EVTd8_Ctrl_KD
- GSM8545606 EVTd8_T007_Ctrl_rep1 EVTd8_T007_Ctrl
- GSM8545607 EVTd8_T007_Ctrl_rep2 EVTd8_T007_Ctrl
- GSM8545608 EVTd8_T007_LGD_rep1 EVTd8_T007_LGD
- GSM8545609 EVTd8_T007_LGD_rep2 EVTd8_T007_LGD
- GSM8545610 EVTd8_T007_rep1 EVTd8_T007
- GSM8545611 EVTd8_T007_rep2 EVTd8_T007
- GSM8545612 EVTd8_Rosi_Ctrl_rep1 EVTd8_Rosi_Ctrl
- GSM8545613 EVTd8_Rosi_Ctrl_rep2 EVTd8_Rosi_Ctrl
- GSM8545614 EVTd8_Rosi_rep1 EVTd8_Rosi
- GSM8545615 EVTd8_Rosi_rep2 EVTd8_Rosi
- GSM8545616 EVTd8_PPARG_d1Dox_rep1 EVTd8_PPARG_d1Dox
- GSM8545617 EVTd8_PPARG_d1Dox_rep2 EVTd8_PPARG_d1Dox
- GSM8545618 EVTd8_PPARG_d3Dox_rep1 EVTd8_PPARG_d3Dox
- GSM8545619 EVTd8_PPARG_d3Dox_rep2 EVTd8_PPARG_d3Dox
- GSM8545620 EVTd8_PPARG_noDox_rep1 EVTd8_PPARG_noDox
- GSM8545621 EVTd8_PPARG_noDox_rep2 EVTd8_PPARG_noDox
- GSM8962900 EVTd8_PPARG_KD1_rep1 EVTd8_PPARG_KD1
- GSM8962901 EVTd8_PPARG_KD1_rep2 EVTd8_PPARG_KD1
- GSM8962902 EVTd8_PPARG_KD2_rep1 EVTd8_PPARG_KD2
- GSM8962903 EVTd8_PPARG_KD2_rep2 EVTd8_PPARG_KD2
- GSE278374 PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [ChIP-seq] 44 samples shares pparg-centric, extravillous, trophoblasts, trophoblast, re-wiring, stem
- GSE295569 PPARG-centric transcriptional re-wiring during differentiation of human trophoblast stem cells into extravillous trophoblasts [ChIP-seq] 15 samples shares pparg-centric, extravillous, trophoblasts, trophoblast, re-wiring, stem
- GSE276594 Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells [RNA-Seq 2] 45 samples shares trophoblast, rna-seq, stem
- GSE276595 Hypoxia and loss of GCM1 expression prevents differentiation and contact inhibition in human trophoblast stem cells [RNA-Seq I] 26 samples shares trophoblast, rna-seq, stem
- GSE337276 DNA methylation maintenance by DNMT1 is essential for human trophoblast stem cell homeostasis and differentiation [RNA-seq] 15 samples shares trophoblast, rna-seq, stem
- GSE307832 DEVELOPMENTAL LANDMARKS AND CELLULAR TRANSITIONS DURING EXTRAVILLOUS TROPHOBLAST CELL DIFFERENTIATION [scRNA-Seq] 11 samples shares extravillous, trophoblast, rna-seq
- GSE236795 Specificity protein 6 governs human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements [RNA-seq] 22 samples shares trophoblast, rna-seq, stem
- GSE288396 Metabolic reprogramming driven by impaired trophoblasts and decidual XCR1+PMN-MDSCs crosstalk controls adverse outcomes in advanced maternal age [RNA-Seq] 14 samples shares trophoblasts, trophoblast, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.