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Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype (10HDA)

GSE266400 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/14 Platform GPL21103
Summary
Primary cortical neurons were obtained from male Cyp19-EGFP mouse embryos at gestational day 15.5. Embryos were genotyped for SRY to determine sex, and only male embryos were used. Cells were seeded in 24-well plates containing 12 mm glass coverslips, coated with 100 µg/mL poly D-lysine to a density of ~0.45 x 106 cells/well and incubated in a humidified CO2 incubator (5% CO2, 37°C). Primary cortical from Cyp19-EGFP mouse embryos were obtained on GD 15.5. Neuronal cell cultures were treated with vehicle or 1mM 10HDA (Matreya, PA ,USA)
Published in
Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype
Symeonides C, Vacy K, Thomson S et al. · Nature communications 2024 · PMID 39112449 · doi:10.1038/s41467-024-48897-8
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Also filed as BioProject PRJNA1106911 and SRA study SRP505244. Searching any of these in the dataset finder brings you back here.

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