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SESN1 alleviates autoimmunity by potentiating STING autophagic degradation

GSE266409 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/05/29 Platform GPL24676
Summary
STING, the pivotal adaptor protein of CGAS-STING signaling, is critical for type I IFN production of innate immunity. However, excessive or prolonged activation of STING is associated with autoinflammatory and autoimmune diseases. Thus, preventing STING from over-activation is important to maintain immune homeostasis. Here, we reported that SESN1 was essential to prevent the excessive activation of STING-mediated type I IFN signaling through autophagic degradation of STING.
Published in
SESN1 negatively regulates STING1 to maintain innate immune homeostasis
Xu L, Zhang H, Qiu Z et al. · Autophagy 2025 · PMID 39945079 · doi:10.1080/15548627.2025.2463148
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Also filed as BioProject PRJNA1107113 and SRA study SRP505294. Searching any of these in the dataset finder brings you back here.

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