NKG2D blockade impairs cytotoxic CD8+ tissue resident memory T cell accumulation and attenuates severity of chronic lung allograft dysfunction after transplantation
Single-cell RNA-seq · human · 15 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 15 samples: 15 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NKG2D blockade impairs tissue-resident memory T cell accumulation and reduces chronic lung allograft dysfunctionJCI insight · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE285515_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1204132 and SRA study SRP554320. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 15 sample titles: 15 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8703717 Multiplexed Lungs 1, T-cells, HTO
- GSM8703718 Multiplexed Lungs 1, T-cells, GEX
- GSM8703719 Multiplexed Lungs 1, T-cells, TCR
- GSM8703720 Multiplexed Hilar Lymph Nodes 1, T-cells, HTO
- GSM8703721 Multiplexed Hilar Lymph Nodes 1, T-cells, GEX
- GSM8703722 Multiplexed Hilar Lymph Nodes 1, T-cells, TCR
- GSM8703723 Multiplexed Lungs and Hilar Lymph Nodes 1, T-cells, HTO
- GSM8703724 Multiplexed Lungs and Hilar Lymph Nodes 1, T-cells, GEX
- GSM8703725 Multiplexed Lungs and Hilar Lymph Nodes 1, T-cells, TCR
- GSM8703726 Multiplexed Lungs 2, T-cells, HTO
- GSM8703727 Multiplexed Lungs 2, T-cells, GEX
- GSM8703728 Multiplexed Lungs 2, T-cells, TCR
- GSM8703729 Multiplexed Hilar Lymph Nodes 2, T-cells, HTO
- GSM8703730 Multiplexed Hilar Lymph Nodes 2, T-cells, GEX
- GSM8703731 Multiplexed Hilar Lymph Nodes 2, T-cells, TCR
- GSE225063 Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity 256 samples shares cd8, cytotoxic
- GSE324044 Contribution of cytotoxic CD8 T cells, neutrophils and type 1 interferon signaling to hyperinflammatory pathology in HIV associated TB meningitis 64 samples shares cd8, cytotoxic
- GSE317789 Single-cell and spatial profiling reveal cDC2A-CXCL13+ CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus 42 samples shares cd8, cytotoxic
- GSE231628 Dysfunctional effector memory CD8 T cells in the bronchoalveolar compartment of people living with HIV 33 samples shares cd8, dysfunction
- GSE277428 NKG2D-mediated cytotoxicity of CD4 cytotoxic T cells in multiple myeloma 27 samples shares nkg2d, cytotoxic
- GSE266486 B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients (human) 21 samples shares cd8, cytotoxic
- GSE316096 Clonal expansion of cytotoxic CD8+ T cells in lecanemab-associated ARIA 18 samples shares cd8, cytotoxic
- GSE266295 A novel immunosenescent CD8+ T cell subset in patients with Ankylosing Spondylitis and Psoriatic Arthritis links spontaneous motility to telomere shortening and dysfunction 16 samples shares cd8, dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.