Mouse lung gene expression comparison between mesenchymal Flcn deletion and wild type control.
RNA-seq (gene expression) · mouse · 11 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 11 samples: 3 × KO_4M vs 3 × WT_4M vs 3 × WT_P7 vs 2 × KO_P7Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hyperactivation of mTORC1 signaling mediates folliculin deficiency-induced pulmonary cyst formation in Birt-Hogg-Dubé syndromeThe Journal of clinical investigation · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266599_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1107818 and SRA study SRP505709. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 11 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8252278 KO_4M_1 KO_4M
- GSM8252279 KO_4M_2 KO_4M
- GSM8252280 KO_4M_3 KO_4M
- GSM8252281 KO_P7_1 KO_P7
- GSM8252282 KO_P7_2 KO_P7
- GSM8252283 WT_4M_1 WT_4M
- GSM8252284 WT_4M_3 WT_4M
- GSM8252285 WT_4M_4 WT_4M
- GSM8252286 WT_P7_2 WT_P7
- GSM8252287 WT_P7_3 WT_P7
- GSM8252288 WT_P7_4 WT_P7
- GSE307127 Immune Receptor Lag3 Deletion Alleviates Neurodegeneration Phenotypes in a Mouse Model of Alzheimer’s Disease 36 samples shares deletion, type
- GSE266417 Female Mice with an Xist Deletion in B Cells Can Develop Lupus-Associated Phenotypes 28 samples shares deletion, type
- GSE335221 Effect of keratinocyte-intrinsic VISTA deletion on UV-induced type I interferon and inflammatory gene expression in mouse epidermis [bulk RNA-seq] 28 samples shares deletion, type
- GSE249931 Temporal single-cell profiling of distinct mesenchymal, epithelial, endothelial, and immune cell lineages in the lung after injury 17 samples shares mesenchymal, lung
- GSE240635 Lysosomal control of type I interferon induction via Ragulator-Rag complex 48 samples shares control, type
- GSE283392 Distinct use of super-enhancer elements controls cell type-specific CD25 transcription and function 25 samples shares control, type
- GSE269191 ZEB2 is a Master Switch Controlling the Tumor-Associated Macrophage Program [in vivo] 145 samples shares control
- GSE274992 Splenic fibroblasts control marginal zone B-cell movement and function via two distinct Notch2-dependent regulatory programs 119 samples shares control
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.