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DHX36-mediated G-quadruplexes unwinding is essential for oocyte and early embryo development in mice

GSE266885 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/01/29 Platform GPL24247
Summary
The role of G-quadruplex (G4) structures and their effects on meiosis resumption and early embryo development remain unclear. We discovered that the G4 helicase DHX36 is essential for oocyte growth and the maternal-to-zygotic transition (MZT). Conditional knockout of DHX36 resulted in DNA G4 accumulation in mouse oocytes, reducing chromatin accessibility, and inhibiting RNA transcription, ultimately disrupting transcriptome homeostasis during oocyte growth and MZT.
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Also filed as BioProject PRJNA1108676 and SRA study SRP506148. Searching any of these in the dataset finder brings you back here.

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