The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen hydroxyprolination and favoring immune infiltration.
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The GLP-1R agonist semaglutide reshapes pancreatic cancer associated fibroblasts reducing collagen proline hydroxylation and favoring T lymphocyte infiltrationJournal of experimental & clinical cancer research : CR · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266899_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1108693 and SRA study SRP506219. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8256220 A1_LFD_T1
- GSM8256221 A2_LFD_T1
- GSM8256222 A3_LFD_T1
- GSM8256223 B1_LFD_T2
- GSM8256224 B2_LFD_T2
- GSM8256225 B4_LFD_T2
- GSM8256226 B5_LFD_T2
- GSM8256227 C1_HFD_T1
- GSM8256228 C3_HFD_T1
- GSM8256229 C4_HFD_T1
- GSM8256230 C5_HFD_T1
- GSM8256231 D1_HFD_T2
- GSM8256232 D2_HFD_T2
- GSM8256233 D3_HFD_T2
- GSM8256234 D5_HFD_T2
- GSM8256235 F2_HFD_SEMA_T2
- GSM8256236 F4_HFD_SEMA_T2
- GSM8256237 F5_HFD_SEMA_T2
- GSE276293 Loss of PARP7 increases IFN-I signalling preventing pancreatic tumour growth by enhancing immune cell infiltration 16 samples shares infiltration, pancreatic
- GSE191008 AXL and MERTK receptor tyrosine kinases inhibition protects against pancreatic necrosis via limiting CXCL2-mediated neutrophil infiltration 12 samples shares infiltration, pancreatic
- GSE279893 Loss of aryl hydrocarbon receptor reduces pancreatic tumor growth by increasing immune cell infiltration 12 samples shares infiltration, pancreatic
- GSE284188 Loss of aryl hydrocarbon receptor reduces pancreatic tumor growth by increasing immune cell infiltration [II] 10 samples shares infiltration, pancreatic
- GSE331086 The CD49b (ITGA2) Collagen Receptor Excludes CD8+ T Cell Infiltration in Pancreatic Ductal Adenocarcinoma (PDAC) 9 samples shares infiltration, pancreatic
- GSE280149 SOAT1 knockout reshapes tumor immune microenvironment with enhanced CD8+ T cell infiltration and effector function [scRNA-seq] 8 samples shares infiltration, reshapes
- GSE280382 Functional and multi-omic aging rejuvenation with GLP-1R agonism [bulk RNA-seq] 620 samples shares glp-1r
- GSE314029 An unimolecular GIPR:GLP-1R:PPAR , , quintuple agonist eliminates obesity and insulin resistance in mice. 159 samples shares glp-1r
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.