GEO series
Effect of TWIST1 dosage changes on chromatin accessibility in hESC-derived cranial neural crest cells
GSE267008
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
20 samples
2024/06/26
GPL24676
Summary
To assess the effects of quantitative TWIST1 dosage changes on chromatin accessibility in hESC-derived cranial neural crest cells, we performed genome editing of the H9 hESC lines to tag TWIST1 with FKBPV36 and V5, Upon differentiating edited hESC to cranial neural crest cells using an established protocol, addition of differing concentrations of the degrader molecule dTAGV-1 results in different TWIST1 concentrations, as measured by V5 intracellular staining and flow cytometry. We then profiled chromatin accessibility in each of these TWIST1 concentrations
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Paper (PMID 38853998) ↗
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