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Effect of mRNA vaccine on Epigenetic and Transcriptomic Profiles of Kupffer Cells (RNA-Seq)

GSE267045 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/06 Platform GPL28457
Summary
The result show that an mRNA/LNP vaccine induced significant numbers of differentially expressed genes (DEG). The analysis identified 123 DEGs between control PBS and mRNA/LNP vaccinated groups where 23 genes and 100 genes were upregulated and downregulated, respectively, in the mRNA/LNP group. To understand the biological changes from the transcriptomic data, gene set enrichment analysis (GSEA) was performed using the whole transcriptome data set. GSEA identified the biological pathways associated with interferon gamma response and protein secretion as the top two ‘Hallmark’ gene sets enriched in OVA mRNA/LNP group, compared to PBS group.
Published in
Effect of mRNA formulated with lipid nanoparticles on the transcriptomic and epigenetic profiles of F4/80(+) liver-associated macrophages
Pongma C, Keawvilai P, Boonmee A et al. · Scientific reports 2025 · PMID 39774150 · doi:10.1038/s41598-025-85234-5
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Also filed as BioProject PRJNA1109402 and SRA study SRP506584. Searching any of these in the dataset finder brings you back here.

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