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Transcriptome analysis and ribosome footprints in engineered chromosome 3 and chromosome 8 isogenic aneuploidy cell model.

GSE267065 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/11/13 Platform GPL24676
Summary
We analyzed two isogenic aneuploidy models. The first model is the chromosome 3 isogenic aneuploidy model, which includes three cell types: chromosome 3 WT, 3q gain, and 3p loss. By comparing with chromosome3 WT, we evaluated the overall transcript expression changes in 3q gain and 3p loss cells. Additionally, by comparing with chromosome3 WT, we assessed the changes in ribosome-protected fragments in 3p loss cells. The second model is the chromosome 8 isogenic aneuploidy model, which includes two cell types: chromosome 8 WT and 8p loss. By comparing with chromosome 8 WT, we evaluated the overall transcript expression changes in 8p loss cells.
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Direct links to NCBI, no account and no request form: the whole study as GSE267065_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1109431 and SRA study SRP506609. Searching any of these in the dataset finder brings you back here.

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