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Epithelial NSD2 maintains FMOs-mediated taurine biosynthesis to prevent intestinal barrier disruption [RNA-Seq]

GSE267227 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/26 Platform GPL24247
Summary
We reported that the deletion of NSD2 in IECs leads to intestinal barrier dysfunction and exacerbates inflammatory infiltration. Further analysis revealed that a deficiency of NSD2 results in decreases of H3K36me2 at protein level and Fmo expression at mRNA level to impede taurine accumulation, both in vitro and in vivo. Supplementation of taurine can effectively alleviate intestinal epithelial damage in NSD2-deficient IBD mice. Thus, these results indicate that NSD2 act as a protector of the intestinal epithelial barrier during intestinal inflammation, which helps maintain intestinal epithelial homeostasis by preventing cell apoptosis.
Published in
Epithelial NSD2 maintains FMO-mediated taurine biosynthesis to prevent intestinal barrier disruption
Xu Y, Xiao X, Ma C et al. · Clinical and translational medicine 2024 · PMID 39658533 · doi:10.1002/ctm2.70128
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Also filed as BioProject PRJNA1110279 and SRA study SRP507053. Searching any of these in the dataset finder brings you back here.

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