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The m6A-mediated TGF-β-SMAD signaling axis regulates ccRCC progression [RNA-seq]

GSE267273 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/05 Platform GPL20301
Summary
TGF-β-SMAD signaling pathway plays an important role in progression of various tumors. However, posttranscriptional regulation such as N6-methyladenosine (m6A) of TGF-β-SMAD signaling axis remains incompletely understood. Here, we reveal that Insulin like growth factor 2 mRNA binding protein 2 (IGF2BP2) is low expression as well as associated with poor prognosis in clear cell renal cell carcinoma (ccRCC) patients and inhibits proliferation as well as promotes metastasis of ccRCC cells. To explore the underlying mechanism of IGF2BP2 in ccRCC, RNA-seq, RIP-seq and LACE-seq were performed to investigate the downstream targets of IGF2BP2.
Published in
N(6)-methyladenosine enhances the expression of TGF-β-SMAD signaling family to inhibit cell growth and promote cell metastasis
Peng B, Cheng S, Wang H et al. · Cancer letters 2024 · PMID 39222678 · doi:10.1016/j.canlet.2024.217195
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Also filed as BioProject PRJNA1110789 and SRA study SRP507212. Searching any of these in the dataset finder brings you back here.

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