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Elevating PLK1 Overcomes BETi-Resistance in Prostate Cancer via Triggering BRD4 Phosphorylation-dependent Degradation in Mitosis

GSE267290 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/06/01 Platform GPL16791
Summary
To investigate the effect of phosphorylated BRD4 at S24 and S1100 on transcription, we established C4-2 stable expressing BRD4 WT, S24/1100A, S24/1100D cell lines in which endogenous BRD4 has been knocked down by shRNA targeted to 3'-UTR. We then performed gene expression profiling analysis using data obtained from RNA-seq of 4 different cells at 18 hour treatment of nocodazole.
Published in
Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis
Zhang Y, Fong KW, Mao F et al. · Cell reports 2024 · PMID 38968071 · doi:10.1016/j.celrep.2024.114431
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Also filed as BioProject PRJNA1111004 and SRA study SRP507287. Searching any of these in the dataset finder brings you back here.

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