IRF2BP2 affects T-ALL cell proliferation by cooperating with master transcription factors
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 19 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Acute lymphoblastic leukemiaThis series is part of our curated briefing on it.
- Samples
- 19 samples: 9 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Super-Enhancer-Driven IRF2BP2 is Activated by Master Transcription Factors and Sustains T-ALL Cell Growth and SurvivalAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE267455_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1111529 and SRA study SRP507194. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 9 replicated groups read from 19 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8263078 J.gamma1 shNC_rep1 J.gamma1 shNC
- GSM8263079 J.gamma1 shNC_rep2 J.gamma1 shNC
- GSM8263080 J.gamma1 shIRF2BP2_rep1 J.gamma1 shIRF2BP2
- GSM8263081 J.gamma1 shIRF2BP2_rep2 J.gamma1 shIRF2BP2
- GSM8266942 J.gamma1,ELF1,CUT&Tag,rep1 J.gamma1,ELF1,CUT&Tag,
- GSM8266943 J.gamma1,ELF1,CUT&Tag,rep2 J.gamma1,ELF1,CUT&Tag,
- GSM8266944 J.gamma1,ERG,CUT&Tag,rep1 J.gamma1,ERG,CUT&Tag,
- GSM8266945 J.gamma1,ERG,CUT&Tag,rep2 J.gamma1,ERG,CUT&Tag,
- GSM8266946 J.gamma1,IRF2BP2,CUT&Tag,rep1 J.gamma1,IRF2BP2,CUT&Ta…
- GSM8266947 J.gamma1,IRF2BP2,CUT&Tag,rep2 J.gamma1,IRF2BP2,CUT&Ta…
- GSM8266948 J.gamma1,RUNX1,CUT&Tag,rep1 J.gamma1,RUNX1,CUT&Tag,
- GSM8266949 J.gamma1,RUNX1,CUT&Tag,rep2 J.gamma1,RUNX1,CUT&Tag,
- GSM8287877 J.gamma1,ETS1,CUT&Tag,rep1 J.gamma1,ETS1,CUT&Tag,
- GSM8287878 J.gamma1,ETS1,CUT&Tag,rep2 J.gamma1,ETS1,CUT&Tag,
- GSM8500529 Irf2bp2 KO, rep1 Irf2bp2 KO,
- GSM8500530 Irf2bp2 KO, rep2 Irf2bp2 KO,
- GSM8500531 Wild type control, rep1 Wild type control,
- GSM8500532 Wild type control, rep2 Wild type control,
- GSM8500533 Wild type control, rep3 Wild type control,
- GSE193713 Genome-wide maps of chromatin state for histone modifications and chromatin remodeling factors in WT and PHF6-KO conditions in Jurkat T-ALL cells. 20 samples same disease briefing · shares t-all, factors
- GSE18198 Expression profile of human T-ALL cell lines treated with DMSO or SAHM1 12 samples same disease briefing · shares t-all
- GSE154675 PHF6 Interacts with LMO2 During Normal Haematopoiesis and in Leukaemia and Regulates the Level of Gene Expression and Genome Integrity 41 samples same disease briefing
- GSE13425 Expression data from ALL patients included in the set used to construct a classification signature (COALL cohort) 190 samples same disease briefing
- GSE12995 Expression data for diagnosis acute lymphoblastic leukemia samples 175 samples same disease briefing
- GSE160298 The chromatin accessibility landscape of T-Cell Acute Lymphoblastic Leukemia 80 samples same disease briefing
- GSE115656 Alternative splicing analysis of pediatric B-cell acute lymphoblastic leukemia compared to normal bone marrow derived pro-B cells 38 samples same disease briefing
- GSE239704 NF-κB transcription factors RelA and c-Rel selectively control CD4+ T-cell function in multiple sclerosis and cancer 34 samples shares transcription, factors
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.