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RNA-seq analysis of parent, RPL22L1 knockout and RPL22 reconstituted HCT116 cells.

GSE267500 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/05/13 Platform GPL24676
Summary
Ribosome biosynthesis is essential for cancer growth and proliferation. This dependency is therapeutically exploitable by blocking the rate-limiting step, RNA polymerase I (Pol I) transcription. We discovered that RPL22 and RPL22L1 were markers for sensitivity to Pol I inhibition. We discovered that their genetic manipulation prominently altered the expression and splicing of a multitude of mRNAs.
Published in
Ribosomal RNA transcription regulates splicing through ribosomal protein RPL22
Fan W, Liu H, Stachelek GC et al. · Cell chemical biology 2025 · PMID 40553690 · doi:10.1016/j.chembiol.2025.05.012
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Also filed as BioProject PRJNA1111739 and SRA study SRP507735. Searching any of these in the dataset finder brings you back here.

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