GEO series
CREM is a regulatory checkpoint of CAR and IL-15 signaling in NK cells
GSE267523
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
32 samples
2025/03/14
GPL24676
Summary
This is a preclinical study investigating the role of CREM transcription factor in CAR NK cells. We found thata CREM is a regulatory checkpoint induced by CAR CD3z signaling and IL-15 stimulation that leads to suppression of NK cell function. CREM KO enhances the anti-tumor efficacy of CAR NK cells.
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NCBI GEO page ↗
Paper (PMID 40468083) ↗
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