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Clinical and molecular characterization of the cisplatin-vinorelbine chemotherapeutic regimen in HER2(-) metastatic breast cancer

GSE267621 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/05/16 Platform GPL24676
Summary
Despite rapid advances in treatment options, challenges still persist in advanced breast cancer. Bevacizumab is a VEGF-neutralizing antibody with proven efficacy in combination with chemotherapy for treatment of HER2 negative metastatic breast cancer (mBC). Vinorelbine, a semisynthetic vinca alkaloid, is a well-established and well tolerated chemotherapeutic in breast cancer. The combination of vinorelbine with platinum and addition of bevacizumab is relatively underreported in the literature. We propose this combination regimen as safe, well tolerated and efficacious in HER2 negative mBC patients.
Published in
Addition of Bevacizumab to Vinorelbine-Platinum combination is efficacious in Heavily Pretreated HER2-Negative Metastatic Breast Cancer
Ho IW, Tseng YR, Liu CY et al. · Journal of Cancer 2025 · PMID 39991566 · doi:10.7150/jca.105199
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Also filed as BioProject PRJNA1108178 and SRA study SRP505964. Searching any of these in the dataset finder brings you back here.

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