IGF2BP3 Promotes Stemness and Leukemogenesis in Acute Myeloid Leukemia
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- m(6)A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerabilityNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268082_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1114628 and SRA study SRP509153. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8285594 MOLM13, shNS, total RNA, rep1 MOLM13, shNS, total RNA,
- GSM8285595 MOLM13, shNS, total RNA, rep2 MOLM13, shNS, total RNA,
- GSM8285596 MOLM13, shBP3-2, total RNA, rep1 MOLM13, shBP3-2, total …
- GSM8285597 MOLM13, shBP3-2, total RNA, rep2 MOLM13, shBP3-2, total …
- GSM8285598 MOLM13, shBP3-1, total RNA, rep1 MOLM13, shBP3-1, total …
- GSM8285599 MOLM13, shBP3-1, total RNA, rep2 MOLM13, shBP3-1, total …
- GSM8285600 U937 BP3-mAID, NT, mRNA, rep1 U937 BP3-mAID, NT, mRNA,
- GSM8285601 U937 BP3-mAID, NT, mRNA, rep2 U937 BP3-mAID, NT, mRNA,
- GSM8285602 U937 BP3-mAID, 6h, mRNA, rep1 U937 BP3-mAID, 6h, mRNA,
- GSM8285603 U937 BP3-mAID, 6h, mRNA, rep2 U937 BP3-mAID, 6h, mRNA,
- GSM8285604 U937 BP3-mAID, 24h, mRNA, rep1 U937 BP3-mAID, 24h, mRN…
- GSM8285605 U937 BP3-mAID, 24h, mRNA, rep2 U937 BP3-mAID, 24h, mRN…
- GSE137851 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia 387 samples same disease briefing · shares leukemia, myeloid, acute
- GSE270185 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia 249 samples same disease briefing · shares leukemia, myeloid, acute
- GSE303795 Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia 6 samples same disease briefing · shares leukemia, myeloid, acute
- GSE137574 Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells 24 samples same disease briefing · shares leukemia, myeloid, acute
- GSE129437 Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown 6 samples same disease briefing
- GSE122515 Bonn Dataset 3 of meta-analysis on AML classification, RNAseq dataset 0 samples same disease briefing
- GSE275859 Acute myeloid leukemia with mixed phenotype is characterized by stemness features with limited lineage plasticity 20 samples shares stemness, leukemia, myeloid, acute
- GSE229736 Therapy Induced Senescence Promotes Immunogenicity in Acute Myeloid Leukemia through Reduced EZH2 Activity (RNA-seq AraC) 12 samples shares promotes, leukemia, myeloid, acute
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.