DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disorders
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 × C vs 4 × DGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- DPYSL2/CRMP2 isoform B knockout in human iPSC-derived glutamatergic neurons confirms its role in mTOR signaling and neurodevelopmental disordersMolecular psychiatry · 2023
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268103_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1114671 and SRA study SRP509182. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8285797 A8_4
- GSM8285798 C7 C
- GSM8285799 D3 D
- GSM8285800 B11_6
- GSM8285801 C8 C
- GSM8285802 D4 D
- GSM8285803 C1 C
- GSM8285804 C9 C
- GSM8285805 C10 C
- GSM8285806 D10 D
- GSM8285807 C2 C
- GSM8285808 D12 D
- GSE262442 Scaled and efficient derivation of loss-of-function alleles in risk genes for neurodevelopmental and psychiatric disorders in human iPSCs 69 samples shares neurodevelopmental, disorders
- GSE271268 Gene expression analysis in obsessive-compulsive disorder with and without comorbid neurodevelopmental disorders 28 samples shares neurodevelopmental, disorders
- GSE327684 RNAseq validation of Neurodevelopmental disorder associated genes knockout efficiency [RNAseq] 19 samples shares neurodevelopmental, knockout
- GSE266958 Pathogenic PPP2R5D variants alters the transcriptome of patient iPSC-derived glutamatergic neurons 18 samples shares glutamatergic, ipsc-derived
- GSE316724 Deep mutational scanning of CHD2 for variant interpretation in neurodevelopmental disorders [RNA-seq] 16 samples shares neurodevelopmental, disorders
- GSE287369 Novel variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders 15 samples shares neurodevelopmental, disorders
- GSE296038 In vitro butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulation 12 samples shares neurodevelopmental, disorders
- GSE306099 Isogenic Wild Type and iPSC-Derived CTBP1 Mutant Neuronal Cells Exhibit Neurodevelopmental Defects 9 samples shares neurodevelopmental, ipsc-derived
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.