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The underlying mechanism of SCNAs-induced lncRNA LOC101927668 overexpressoin facilitating colorectal cancer progression

GSE268122 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/15 Platform GPL24676
Summary
Somatic copy number alterations (SCNAs) are pivotal in cancer progression and patient prognosis. Dysregulated long non-coding RNAs (lncRNAs), modulated by SCNAs, significantly impact tumorigenesis, including colorectal cancer (CRC). Nonetheless, the functional significance of lncRNAs induced by SCNAs in CRC remains largely unexplored. In this study, we elucidate that the overexpression of LOC101927668, driven by SCNAs, facilitates CRC proliferation and metastasis by recruiting hnRNPD, thus perturbing the RBM47/P53/P21 signaling pathway.
Published in
Copy number amplification-induced overexpression of lncRNA LOC101927668 facilitates colorectal cancer progression by recruiting hnRNPD to disrupt RBM47/p53/p21 signaling
Wang Z, Han H, Zhang C et al. · Journal of experimental & clinical cancer research : CR 2024 · PMID 39350250 · doi:10.1186/s13046-024-03193-7
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Also filed as BioProject PRJNA1091872 and SRA study SRP497831. Searching any of these in the dataset finder brings you back here.

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