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The effects on the deficient of GDH1 on gene expression in LN229 cells.

GSE268158 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/30 Platform GPL24676
Summary
Glutamine is an important nutriment for cancer cell growth that provides biological sources for nucleic acid and fatty acid synthesis, but the role of glutaminolysis in signal transduction and glioblastoma (GBM) progression remains little known. Here, we investigated whether GDH1, a key glutamate dehydrogenase, affects the expression levels of signal transduction factors by mRNA expression profiling of wild-type and GDH1 knockdown cells of the glioblastoma cell line LN229 cells
Published in
Glutamate dehydrogenase 1-catalytic glutaminolysis feedback activates EGFR/PI3K/AKT pathway and reprograms glioblastoma metabolism
Yang R, Zhang G, Meng Z et al. · Neuro-oncology 2025 · PMID 39446525 · doi:10.1093/neuonc/noae222
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Also filed as BioProject PRJNA1114777 and SRA study SRP509288. Searching any of these in the dataset finder brings you back here.

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