Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD)
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 4 × normal chow diet mice, vs 4 × high-fat diet mice, vs 4 × high-fat diet mice, treated with NM-FGF19,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Non-mitogenic FGF19 mRNA-based therapy for the treatment of experimental metabolic dysfunction-associated steatotic liver disease (MASLD)Clinical science (London, England : 1979) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268200_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1115115 and SRA study SRP509421. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 4 samples read as cases, 4 as controls.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8287711 normal chow diet mice, replicate 1 normal chow diet mice,
- GSM8287712 normal chow diet mice, replicate 2 normal chow diet mice,
- GSM8287713 normal chow diet mice, replicate 3 normal chow diet mice,
- GSM8287714 normal chow diet mice, replicate 4 normal chow diet mice,
- GSM8287715 high-fat diet mice, replicate 1 high-fat diet mice,
- GSM8287716 high-fat diet mice, replicate 2 high-fat diet mice,
- GSM8287717 high-fat diet mice, replicate 3 high-fat diet mice,
- GSM8287718 high-fat diet mice, replicate 4 high-fat diet mice,
- GSM8287719 high-fat diet mice, treated with NM-FGF19, replicate 1 high-fat diet mice, tre…
- GSM8287720 high-fat diet mice, treated with NM-FGF19, replicate 2 high-fat diet mice, tre…
- GSM8287721 high-fat diet mice, treated with NM-FGF19, replicate 3 high-fat diet mice, tre…
- GSM8287722 high-fat diet mice, treated with NM-FGF19, replicate 4 high-fat diet mice, tre…
- GSE238201 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) [RNA-seq] 12 samples shares masld, steatotic
- GSE239279 Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) 24 samples shares masld, steatotic
- GSE319035 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease [NAFLD_time_course] 77 samples shares dysfunction-associated, steatotic
- GSE283060 Humanized Monoacylglycerol Acyltransferase 2 mice Become Obese and develop Metabolic Dysfunction-Associated Steatotic Liver Disease when fed a High Fat Diet 64 samples shares dysfunction-associated, steatotic
- GSE275176 Transcriptomic alterations associated with the progression of metabolic dysfunction-associated steatotic liver disease in CC042 Collaborative Cross mice. 60 samples shares dysfunction-associated, steatotic
- GSE312316 Maternal Western-Style Diet alters Kupffer Cell proportion leading to Metabolic Dysfunction-Associated Steatotic Liver Disease when challenged with western diet in adulthood 36 samples shares dysfunction-associated, steatotic
- GSE318801 P21+TREM2+-Senescent Macrophages Fuel Inflammaging and Metabolic Dysfunction-Associated Steatotic Liver Disease. 20 samples shares dysfunction-associated, steatotic
- GSE312061 Liver-specific delivery of MDM2 antisense oligonucleotides counteracts diet-induced metabolic dysfunction-associated steatotic liver diseases 18 samples shares dysfunction-associated, steatotic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.