Dual specificity phosphatase 6 (DUSP6) deletion protects mice and reduces disease severity in autoimmune arthritis.
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × SPL_HOM vs 5 × SPL_WTGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- DUSP6 deletion protects mice and reduces disease severity in autoimmune arthritisiScience · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE268216_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1115144 and SRA study SRP509454. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8288082 SPL_HOM26 SPL_HOM
- GSM8288083 SPL_HOM21 SPL_HOM
- GSM8288084 SPL_HOM73 SPL_HOM
- GSM8288085 SPL_HOM01 SPL_HOM
- GSM8288088 SPL_HOM03 SPL_HOM
- GSM8288091 SPL_WT65 SPL_WT
- GSM8288093 SPL_WT67 SPL_WT
- GSM8288096 SPL_WT73 SPL_WT
- GSM8288099 SPL_WT77 SPL_WT
- GSM8288102 SPL_WT83 SPL_WT
- GSE269514 Age-Related Retinal Degeneration Resulting from the Deletion of Shp2 Tyrosine Phosphatase in Photoreceptor 12 samples shares phosphatase, deletion
- GSE240693 Circadian-affected tissue specificity is linked to aging and longevity 144 samples shares specificity
- GSE240689 Circadian-affected tissue specificity is linked to aging and longevity [sleep deprivation experiment] 96 samples shares specificity
- GSE227937 MicroRNA-150 controls experimental autoimmune encephalomyelitis by regulating CD4 T cell differentiation and function 69 samples shares autoimmune
- GSE303699 Autoimmune Disease Risk Gene ANKRD55 Promotes Th17 Effector Function Through Metabolic Modulation [RNA-Seq] 60 samples shares autoimmune
- GSE227557 Circadian-affected tissue specificity is linked to aging and longevity [Differential expression analysis of liver and kidney] 48 samples shares specificity
- GSE263577 Fecal microbiota transfer from autoimmune dry eye disease model mice to conventional mice induces ocular surface inflammation and stereotypic B cell receptor repertoire development in lacrimal gland 48 samples shares autoimmune
- GSE271029 Mex3a-dependent post-transcriptional silencing assures olfactory receptor diversity and axon guidance specificity [RNA-Seq] 46 samples shares specificity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.