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Effect of IFN-γ on gene expression of bone marrow-derived macrophages

GSE268403 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/30 Platform GPL24247
Summary
Here, we report that IFN-γ derived from CD8+ T cells promotes the transcription of ACOD1 in macrophages and the subsequent production of itaconate. To explore the molecular mechanism by which IFN-γ induces ACOD1 in macrophages, we analysed the transcriptome of IFN-γ-treated BMDMs by RNA-seq. Enrichment analysis of differentially expressed genes (DEGs) revealed that the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway was significantly enriched in IFN-γ-treated BMDMs compared with the control group.
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Also filed as BioProject PRJNA1117033 and SRA study SRP510110. Searching any of these in the dataset finder brings you back here.

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