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Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1

GSE268418 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/06/16 Platform GPL24676
Summary
Enterovirus A71 (EV-A71) is a single-stranded, positive sense RNA virus causing endoplasmic reticulum stress to induce or modulate downstream signaling pathways known as the unfolded protein responses (UPR). The 3A protein of EV-A71 was identified as a major regulator of the UPR caused by infection with EV-A71. To identify the molecular pathways for the 3A protein to regulate the UPR, we performed RNA sequencing (RNA-seq) with RD cells expressing the 3A protein. Wild type or defective mutant of 3A protein that carried alanine substitutions of Ile8 or Ile10 (3A-I8A or -I10A) was expressed in the cells. The RNA-seq with cells expressing either WT or mutant 3A was performed.
Published in
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1
Hirano J, Hayashi T, Kitamura K et al. · Journal of virology 2024 · PMID 38904364 · doi:10.1128/jvi.00813-24
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Also filed as BioProject PRJNA1117064 and SRA study SRP510157. Searching any of these in the dataset finder brings you back here.

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