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Effect of LINC01871 silencing on CD4+ T cell activation.

GSE268455 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/08/27 Platform GPL24676
Summary
Long intergenic noncoding RNAs (lincRNAs) play crucial roles in regulating biological processes in health and disease. However, little is known about the contribution of lincRNAs in T-cell activation. Here, we identified a lincRNA, LINC01871, which is highly induced upon T-cell activation and is predominantly located in the cytoplasm. The anti-inflammatory cytokine TGF-β was found to suppress its expression. Silencing LINC01871 led to a modest decrease in IL-2 secretion. RNA-seq and proteomic analyses of LINC01871-deficient CD4+ T cells revealed several targets, including genes associated with autophagy and membrane organization such as ATG2B; TRIM5; SNX30; TIMM8B; and ATP10A. Notably, LINC01871 expression was highly specific to T cells in several cross tissue single cell RNA-seq atlases. Furthermore, ex-vivo CD4+ T cells from children progressing to beta-cell autoimmunity showed higher LINC01871 expression as compared to their age, sex and HLA-risk matched controls. These data suggest that LINC01871 has an in-vivo function in T-cell-mediated immunity.
Published in
LINC01871 is exclusively expressed in T and NK cells and is highly induced upon CD4(+) T cell activation
Kalim UU, Shetty A, Ranade A et al. · iScience 2025 · PMID 41244587 · doi:10.1016/j.isci.2025.113779
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Also filed as BioProject PRJNA1117406 and SRA study SRP510259. Searching any of these in the dataset finder brings you back here.

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