GEO series
The Hippo pathway and p27Kip1 cooperate to suppress sensory receptor regeneration in the organ of Corti and the retina.
GSE268504
Mus musculus
Expression profiling by high throughput sequencing
15 samples
2025/04/23
GPL21103
Summary
The mammalian auditory sensory organ, the organ of Corti, has no capacity for regenerating lost hair cells, leading to permanent hearing impairment. In this study, we demonstrate that auditory supporting cells resist Yap activation after Hippo inhibition and uncover the molecular mechanism maintaining quiescence in the adult cochlear supporting cells.
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Paper (PMID 40178894) ↗
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