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The target gene investigation in osteoclats (OCs) treated with mmu-miR-5112 enriched in EVs from OCs with prostate cancer (PCa) cells [target_EV-miR-5112]

GSE268550 Mus musculus Expression profiling by high throughput sequencing 5 samples Submitted 2024/06/06 Platform GPL24247
Summary
Bone metastatic lesions of PCa contain areas of bone destruction and formation that are directed by OCs and osteoblasts (OBs), respectively. OC-derived EVs are reported to maintain normal bone homeostasis; however, there is no study investigating the role of EVs from OCs in the presence of PCa. We identified mmu-miR-5112 enriched in EVs from OCs co-cultured with several PCa cell lines. NGS analyses were performed to investigate predicted target genes of EV-mmu-miR-5112 in OCs.
Published in
Extracellular Vesicles From Prostate Cancer-Corrupted Osteoclasts Drive a Chain Reaction of Inflammatory Osteolysis and Tumour Progression at the Bone Metastatic Site
Tamura T, Yamamoto T, Kogure A et al. · Journal of extracellular vesicles 2025 · PMID 40545975 · doi:10.1002/jev2.70091
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Also filed as BioProject PRJNA1117788 and SRA study SRP510452. Searching any of these in the dataset finder brings you back here.

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