GEO series
Small molecules that induce proliferation of human iPSC-cardiomyocytes
GSE268693
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2024/06/16
GPL18573
Summary
We selected a set of five compounds with diverse known targets that induce proliferation of human iPSC-derived cardiomyocytes. We performed bulk RNA-sequencing of human iPSC-CMs in response to the five compounds to identify common mechanisms mediating compound-induced cell cycle progression. Transcriptome profiling revealed these compounds all induced a common set of pathways including cell cycle, DNA repair, and kinesins.
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Paper (PMID 39171295) ↗
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