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Effector differentiation and therapeutic reinvigoration of CD8+ T cells in chronic infection depend on KLF2-directed lymph node homing

GSE268824 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2025/08/05 Platform GPL24247
Summary
In this study, we examine the heterogeneity and molecular regulation of CD8 T cells in chronic infection across lymph nodes and spleen. We find that lymph nodes, not the spleen, support the stemness and polyfunctionality of CD8 T cells and their response to PD-1 blocking therapy. We discover that the transcription factor KLF2 is specifically expressed in and required for stem-like precursor and effector-like T cells. Finally, we show that migratory dendritic cell in the lymph nodes support the differentiation and function of CD8 T cells.
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Also filed as BioProject PRJNA1118800 and SRA study SRP511118. Searching any of these in the dataset finder brings you back here.

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