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Olanzapine suppresses mPFC-norepinephrine releasing to alleviate CLOCK-induced cancer stemness under chronic stress

GSE268860 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/08/02 Platform GPL24676
Summary
We identify a new mechanism by which OLZ ameliorates chronic stress-enhanced tumorigenesis and chemoresistance. OLZ reversed chronic stress-enhanced lung tumorigenesis and anxiety-like behaviors by suppressing neuro-activity in the mPFC and reducing norepinephrine (NE) releasing. To investigate the mechanism of NE in cancer stemness we performed RNA-seq of the NCI-H1299 cells under NE treatment and found that NE activated β2-adrenoceptor (ADRB2)-mediated cAMP-PKA-CREB pathway to transactivate CLOCK that further sustains cancer stemness.
Published in
Olanzapine suppresses mPFC activity-norepinephrine releasing to alleviate CLOCK-enhanced cancer stemness under chronic stress
Lu J, Zhang X, Su K et al. · Cell communication and signaling : CCS 2024 · PMID 39054537 · doi:10.1186/s12964-024-01747-y
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Also filed as BioProject PRJNA1119202 and SRA study SRP511228. Searching any of these in the dataset finder brings you back here.

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