GEO series
Molecular Profile of Interleukin-17RA Blockade by Brodalumab in Japanese Patients with Psoriasis: Results from the ESPRTI study
GSE268958
Homo sapiens
Expression profiling by high throughput sequencing
163 samples
2025/12/31
GPL24676
Summary
Brodalumab, an anti-interleukin-17 receptor antibody, is presumed to be effective in psoriasis due to its action on the IL-17 pathway. This study is an analysis of an exploratory intervention study (ESPRIT) conducted in Japanese patients with moderate to severe plaque psoriasis. The efficacy of brodalumab was analyzed by clinical changes and modulation of skin inflammation by changes in gene expression in the skin and protein expression in blood samples.
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Paper (PMID 41077515) ↗
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