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Downregulation of MED12 via siRNA in 22Rv1 prostate cancer cells (full transcriptome)

GSE269070 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/09/26 Platform GPL24676
Summary
The Mediator complex is a multi-subunit protein that modulates gene expression on a genome-wide scale. MED12 and cyclin-dependent kinase 8 (CDK8) or its paralog CDK19 are components of its kinase module that regulate the proliferation of prostate cancer cells. In this study, we investigated how MED12 and CDK8/19 influence cancer-driven processes in prostate cancer cell lines, focusing on AR activity and enzalutamide resistance.
Published in
MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer
Andolfi C, Bartolini C, Morales E et al. · Endocrinology 2024 · PMID 39253786 · doi:10.1210/endocr/bqae114
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Also filed as BioProject PRJNA1120052 and SRA study SRP512171. Searching any of these in the dataset finder brings you back here.

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