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Effect of OPA1 loss on expression of genes associated with cellular susceptibility to ferroptosis

GSE269167 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/08/13 Platform GPL21103
Summary
OPA1 is a dynamin-related GTPase that plays a critial role in governing mitochondrial fusion, cristae structure, and energetics. Here we found that OPA1 functions as a postive regulator of a nonapoptotic form of cell death termed ferroptosis. Although we determined that the OPA1 GTPase activity is required to drive ferroptosis, the fusogenic activity of OPA1 is dispensable for ferroptosis execution. Mechanistically, our studies show that OPA1 promotes ferroptosis through distinct mechanisms involving the generation of mitochondrial reactive oxygen species and suppression of the integrated stress response.
Published in
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
Liang FG, Zandkarimi F, Lee J et al. · Molecular cell 2024 · PMID 39142278 · doi:10.1016/j.molcel.2024.07.020
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Also filed as BioProject PRJNA1120446 and SRA study SRP512024. Searching any of these in the dataset finder brings you back here.

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