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Effect of decitabine on gene expression in THP-1 or decitabine-resistant THP-1 leukemia cells

GSE269185 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/06/28 Platform GPL24676
Summary
To globally evaluate transcriptome in THP-1 and decitabine-resistant THP-1 cells treated by decitabine, cells were treated with the IC90 dose of decitabine until 90% cell death was reached, then cultured in decitabine-free medium until confluence, followed by another round of decitabine treatment and the treatment cycles were repeated for 3 months to generate decitabine-resistant THP-1 cells. We then performed gene expression profiling analysis using data obtained from RNA-seq of THP-1 or decitabine-resistant THP-1 cells treated with or without decitabine.
Published in
RIG-I-Inducing Small Molecules Potently Inhibit HMA-Resistant AML Through Igniting the Overloaded dsRNA Arsenal
Chen X, Wu J, Li Y et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 40568903 · doi:10.1002/advs.202414477
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Also filed as BioProject PRJNA1120476 and SRA study SRP512054. Searching any of these in the dataset finder brings you back here.

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