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PI3Kg in B cells promotes antibody responses and generation of antibody-secreting cells [scRNA-seq]

GSE269300 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/06/26 Platform GPL24247
Summary
The differentiation of naïve and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for phosphoinositide 3-kinase delta (PI3Kδ) to support B cell biology has been investigated intensively; however, specific functions of the related phosphoinositide 3-kinase-gamma (PI3Kγ) complex in B-lineage cells have not. Here we report that PI3Kγ promotes robust antibody responses induced by T cell-dependent antigens. The inborn error of immunity caused by human deficiency in PI3Kγ results in broad humoral defects, prompting our investigation of roles for this kinase in antibody responses using mouse models with bulk and single-cell transcriptome as well as B cell receptor repertoire sequencing.
Published in
PI3Kγ in B cells promotes antibody responses and generation of antibody-secreting cells
Lanahan SM, Yang L, Jones KM et al. · Nature immunology 2024 · PMID 38961274 · doi:10.1038/s41590-024-01890-1
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Also filed as BioProject PRJNA1120924 and SRA study SRP512315. Searching any of these in the dataset finder brings you back here.

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