Phase Ib/II Study of Azacitidine, Venetoclax and Magrolimab in Adult Patients with Newly Diagnosed and Relapsed Refractory Acute Myeloid Leukemia
Single-cell RNA-seq · human · 27 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 27 samples: 27 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Azacitidine, Venetoclax, and Magrolimab in Newly Diagnosed and Relapsed Refractory Acute Myeloid Leukemia: Phase Ib/II Study and Correlative AnalysisClinical cancer research : an official journal of the American Association for Cancer Research · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269669_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1123202 and SRA study SRP513575. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 27 sample titles: 27 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8324384 Patient1A, scRNA-seq
- GSM8324385 Patient1B, scRNA-seq
- GSM8324386 Patient1C, scRNA-seq
- GSM8324387 Patient2A, scRNA-seq
- GSM8324388 Patient2B, scRNA-seq
- GSM8324389 Patient3A, scRNA-seq
- GSM8324390 Patient3B, scRNA-seq
- GSM8324391 Patient3C, scRNA-seq
- GSM8324392 Patient4A, scRNA-seq
- GSM8324393 Patient4B, scRNA-seq
- GSM8324394 Patient4C, scRNA-seq
- GSM8324395 Patient5A, scRNA-seq
- GSM8324396 Patient5B, scRNA-seq
- GSM8324397 Patient6A, scRNA-seq
- GSM8324398 Patient6B, scRNA-seq
- GSM8324399 Patient7A, scRNA-seq
- GSM8324400 Patient7B, scRNA-seq
- GSM8324401 Patient7C, scRNA-seq
- GSM8324402 Patient8A, scRNA-seq
- GSM8324403 Patient8B, scRNA-seq
- GSM8324404 Patient9A, scRNA-seq
- GSM8324405 Patient9B, scRNA-seq
- GSM8324406 Patient10A, scRNA-seq
- GSM8324407 Patient10B, scRNA-seq
- GSM8324408 Patient10C, scRNA-seq
- GSM8324409 Patient11A, scRNA-seq
- GSM8324410 Patient11B, scRNA-seq
- GSE137851 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia 387 samples same disease briefing · shares leukemia, myeloid
- GSE270185 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia 249 samples same disease briefing · shares leukemia, myeloid
- GSE303795 Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia 6 samples same disease briefing · shares leukemia, myeloid
- GSE137574 Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells 24 samples same disease briefing · shares leukemia, myeloid
- GSE129437 Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown 6 samples same disease briefing
- GSE122515 Bonn Dataset 3 of meta-analysis on AML classification, RNAseq dataset 0 samples same disease briefing
- GSE311458 Phase 1 study of chidamide in combination with venetoclax, azacitidine, aclarubicin, cytarabine and G-CSF for refractory/relapsed acute myeloid leukemia: Clinical safety, efficacy and correlative analysis 8 samples shares azacitidine, venetoclax, refractory, relapsed, leukemia, myeloid
- GSE289786 Improved Prediction of Venetoclax and Azacitidine Efficacy in Acute Myeloid Leukemia through Machine Learning [AML patients] 142 samples shares azacitidine, venetoclax, leukemia, myeloid
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.