Dissecting AP-1 complexity in hepatic health and disease using Genetically Modified Mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- c-Jun and Fra-2 pair up to Myc-anistically drive HCCCell cycle (Georgetown, Tex.) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE269844_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1124002 and SRA study SRP513928. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 6 samples read as cases, 6 as controls.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8328822 control-1 -Fra1hep - 2 months [LB04001]
- GSM8328823 control-2 -Fra1hep - 2 months [LB04002]
- GSM8328824 control-3 -Fra1hep - 2 months [LB04003]
- GSM8328825 mutant-1 -Fra1hep - 2 months [LB04004]
- GSM8328826 mutant-2 -Fra1hep - 2 months [LB04005]
- GSM8328827 mutant-3 -Fra1hep - 2 months [LB04006]
- GSM8328828 control-1 -Fra2hep - 2 months [LB04007]
- GSM8328829 control-2 -Fra2hep - 2 months [LB04008]
- GSM8328830 control-3 -Fra2hep - 2 months [LB04009]
- GSM8328831 mutant-1 -Fra2hep - 2 months [LB04010]
- GSM8328832 mutant-2 -Fra2hep - 2 months [LB04011]
- GSM8328833 mutant-3 -Fra2hep - 2 months [LB04012]
- GSE275728 Transcriptome analysis of pancreatic cancer cells with genetically modified Ptges or Ptger4 36 samples shares genetically, modified
- GSE273079 Castration Increases Aggressiveness of Prostatic Luminal Progenitor Cells in Prostate Cancer Through FosL1/AP-1-Mediated Transcriptional Reprogramming 384 samples shares ap-1
- GSE325918 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by regulating expression of AP-1 transcription factors and their target genes [RNA-seq] 32 samples shares ap-1
- GSE230719 AP-1 inhibition in DRG neurons by A-Fos dominant negative construct 30 samples shares ap-1
- GSE274016 Nuclear receptor Nur77 resolves the inflammatory response of macrophages primarily by cis- and trans-regulation of AP-1 target genes [RNA-Seq] 24 samples shares ap-1
- GSE261005 Liver cancer development driven by the AP-1/c-Jun~Fra2 dimer through c-Myc 19 samples shares ap-1
- GSE310249 Modulating AP-1 enables CAR-T cells to establish an intratumoral stem-like reservoir and overcomes resistance to PD-1 blockade 18 samples shares ap-1
- GSE310740 Modulating AP-1 enables CAR-T cells to establish an intratumoral stem-like reservoir and overcomes resistance to PD-1 blockade 16 samples shares ap-1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.