Dissecting AP-1 complexity in hepatic health and disease using Genetically Modified Mice

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death with limited, while treatment options. Thus, a better understanding of the molecular pathways involved in HCC development has become a priority to guide future therapies. While previous studies implicated the AP-1 (Fos/Jun) transcription factor family members c-Fos and c-Jun in HCC formation, the contribution of Fos-related antigens 1 and 2 (Fra-1/2) is unknown. Here we analyse the transcriptional consequences of hepatocyte-restricted expression of Fra-1 and Fra-2 proteins in the liver of young adult mice during 2 months by bulk RNA-seq.