Transcriptome analysis of pancreatic cancer cells with genetically modified Ptges or Ptger4
RNA-seq (gene expression) · mouse · 36 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 36 samples: 9 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Pivotal roles for cancer cell-intrinsic mPGES-1 and autocrine EP4 signaling in suppressing antitumor immunityJCI insight · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275728_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1152336 and SRA study SRP528568. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 8 samples read as cases, 8 as controls.
How we read this: 9 replicated groups read from 36 sample titles; they account for 36 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8483547 In vivo bulk control1 In vivo bulk control
- GSM8483548 In vivo bulk control2 In vivo bulk control
- GSM8483549 In vivo bulk control3 In vivo bulk control
- GSM8483550 In vivo bulk control4 In vivo bulk control
- GSM8483551 In vivo bulk control5 In vivo bulk control
- GSM8483552 In vivo bulk EP4 KO1 In vivo bulk EP4 KO
- GSM8483553 In vivo bulk EP4 KO2 In vivo bulk EP4 KO
- GSM8483554 In vivo bulk EP4 KO3 In vivo bulk EP4 KO
- GSM8483555 In vivo bulk EP4 KO4 In vivo bulk EP4 KO
- GSM8483556 In vivo bulk EP4 KO5 In vivo bulk EP4 KO
- GSM8483557 In vivo bulk Ptges KO1 In vivo bulk Ptges KO
- GSM8483558 In vivo bulk Ptges KO2 In vivo bulk Ptges KO
- GSM8483559 In vivo bulk Ptges KO3 In vivo bulk Ptges KO
- GSM8483560 In vivo bulk Ptges KO4 In vivo bulk Ptges KO
- GSM8483561 In vivo bulk Ptges KO5 In vivo bulk Ptges KO
- GSM8483562 In vitro control1 In vitro control
- GSM8483563 In vitro control2 In vitro control
- GSM8483564 In vitro control3 In vitro control
- GSM8483565 In vitro EP4 KO1 In vitro EP4 KO
- GSM8483566 In vitro EP4 KO2 In vitro EP4 KO
- GSM8483567 In vitro EP4 KO3 In vitro EP4 KO
- GSM8483568 In vitro Ptges KO1 In vitro Ptges KO
- GSM8483569 In vitro Ptges KO2 In vitro Ptges KO
- GSM8483570 In vitro Ptges KO3 In vitro Ptges KO
- GSM8483571 In vivo sorted tumor control1 In vivo sorted tumor co…
- GSM8483572 In vivo sorted tumor control2 In vivo sorted tumor co…
- GSM8483573 In vivo sorted tumor control3 In vivo sorted tumor co…
- GSM8483574 In vivo sorted tumor control4 In vivo sorted tumor co…
- GSM8483575 In vivo sorted tumor EP4 KO1 In vivo sorted tumor EP…
- GSM8483576 In vivo sorted tumor EP4 KO2 In vivo sorted tumor EP…
- GSM8483577 In vivo sorted tumor EP4 KO3 In vivo sorted tumor EP…
- GSM8483578 In vivo sorted tumor EP4 KO4 In vivo sorted tumor EP…
- GSM8483579 In vivo sorted tumor Ptges KO1 In vivo sorted tumor Pt…
- GSM8483580 In vivo sorted tumor Ptges KO2 In vivo sorted tumor Pt…
- GSM8483581 In vivo sorted tumor Ptges KO3 In vivo sorted tumor Pt…
- GSM8483582 In vivo sorted tumor Ptges KO4 In vivo sorted tumor Pt…
- GSE241850 Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer progression via extracellular vesicle transfer of m6A-modified RNAs 57 samples shares pancreatic, modified
- GSE269844 Dissecting AP-1 complexity in hepatic health and disease using Genetically Modified Mice 12 samples shares genetically, modified
- GSE218178 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance 183 samples shares pancreatic
- GSE218173 Adaptation to an acid microenvironment promotes pancreatic cancer organoid growth and drug resistance [acid] 150 samples shares pancreatic
- GSE271004 Transcriptional Analyses of Acinar- And Ductal-Cell-Derived Pancreatic Cancer 59 samples shares pancreatic
- GSE325195 Dendritic cell redundancy enables priming of anti-tumor CD4 T cells in pancreatic cancer 30 samples shares pancreatic
- GSE324743 Hepatocytes promote liver metastasis of pancreatic cancer by providing exogenous serine 24 samples shares pancreatic
- GSE306986 Synergistic Stromal Remodeling and Dual Chemo-Immunotherapy in Pancreatic Cancer: A Two-Stage Losartan-Primed followed Nanocarrier Strategy for Tumor Microenvironment Reprogramming 24 samples shares pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.