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Transcriptome analysis of the effect of HERV-K env gene knockout in ovarian cancer cell lines

GSE269969 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/10/31 Platform GPL24676
Summary
Transcriptome analysis revealed that 23 differentially expressed genes (DEGs) were upregulated and 17 DEGs were downregulated in SKOV3 cells. In OVCAR3 cells, 198 DEGs were upregulated, and 17 DEGs were downregulated. Notably, 53 DEGs exhibited statistically significant differences among the 1,612 DEGs identified. Our findings indicate that HERV-K env gene KO exerts a profound influence on gene expression patterns in OVCAR3 cells, while genetic alterations in expression were relatively modest in SKOV3 cells. Nevertheless, genes ND1, ND2, and CYTB displayed a common increase in expression, while ERRFI1 and NDRG1 exhibited a decrease in expression in both cell lines.
Published in
Transcriptome analysis of the effect of HERV-K env gene knockout in ovarian cancer cell lines
Ko EJ, Suh DS, Kim H et al. · Genes & genomics 2024 · PMID 39271536 · doi:10.1007/s13258-024-01544-4
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Also filed as BioProject PRJNA1124526 and SRA study SRP514206. Searching any of these in the dataset finder brings you back here.

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