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The role of Spp1 in pancreatic cancer

GSE269971 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/08/11 Platform GPL24247
Summary
We performed RNA-seq analysis on Spp1 wild-type and CRISPR/Cas9-mediated Spp1 knock out pancreatic tumour organiod from Pdx1-Flp;KrasFSF-G12D;Trp53frt/frt; Vim-EGFP (KPFV) mice. We compared the transcriptome between these two groups of them with the aim to understand their molecular signatures and the relevance to human pancreatic ductal adenocarcinoma subtypes.
Published in
SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer
Li H, Lan L, Chen H et al. · Nature 2025 · PMID 40993391 · doi:10.1038/s41586-025-09574-y
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Also filed as BioProject PRJNA1124529 and SRA study SRP514211. Searching any of these in the dataset finder brings you back here.

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